Enhancement of complexation of drug: binary and ternary mixtures
Bhati et al. enhancement of complexation
The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HPß-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HPß-CD was about 6.23 times higher than that in the binary system. Results…
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Produktdetails
Weitere Autoren: Bhati, Meena / Tiwari, Gaurav
- ISBN: 978-3-8484-9390-6
- EAN: 9783848493906
- Produktnummer: 37751262
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2012
- Seitenangabe: 120 S.
- Masse: H22.0 cm x B15.0 cm x D0.7 cm 197 g
- Abbildungen: Paperback
- Gewicht: 197
Über den Autor
Lokesh bhati is presently a research scientist in mankind research laboratory, gurgaon, India. He is presently the reviewer of many indexed journals. He has many publications in national and international journals.He has five years of research experience in controlled and targetted drug delivery.
1 weiteres Werk von Lokesh Kumar Bhati:
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