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Xiaodong (Hrsg.) Liu

Drug Transporters in Drug Disposition, Effects and Toxicity

Buch

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neu… Mehr

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Produktdetails


Weitere Autoren: Pan, Guoyu (Hrsg.)
  • ISBN: 978-981-1376-46-7
  • EAN: 9789811376467
  • Produktnummer: 30315019
  • Verlag: Springer Nature
  • Sprache: Englisch
  • Erscheinungsjahr: 2019
  • Seitenangabe: 580 S.
  • Masse: H24.4 cm x B15.9 cm x D3.5 cm 1'118 g
  • Auflage: 2019
  • Reihenbandnummer: 1141
  • Gewicht: 1118

Über den Autor


Dr. Xiaodong Liu is a Professor at the College of Pharmacy, China Pharmaceutical University,. He was the chairman of the Chinese Pharmacological Society's drug metabolism professional commission (CSSX).  Dr. Liu is also an active member of the Pharmacological Association and International Society for the Study of Xenobiotics (ISSX). Dr. Liu received the Second Award of National Science and Technology Progress (2nd) and the First Award of Jiangsu Province Science and Technology Progress (2nd). His research focuses on the pharmacokinetics in TCM, ABC transporter and blood brain barrier, drug-drug interactions and the effects of diseases on CYP450s/drug transporters, and he has published over 150 papers in these fields.Dr. Guoyu Pan is a principle investigator at Shanghai Institute of Materia Medica, Chinese Academy of Sciences. He is a standing committee member of the cell therapy research and application branch of the Chinese Society of Cell Biology and the associate director of the CSSX youth committee. Dr. Pan's research focuses on drug transporters and metabolic- enzyme-related liver and kidney injury, cellular pharmacokinetics and cell-therapy safety. He has published over 40 research articles in these fields.

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