Himanshu Gupta

Development of in situ gel system for ocular drug delivery

Physiologically active mucoadhesive sol to gel system

Buch

In situ gel-forming systems have drawn much attention of current researchers to overcome the poor bioavailability from the conventional eye drops. The present work described formulation and pharmacoscintigraphic evaluation of timolol-maleate-loaded chitosan/hydroxy propyl methyl cellulose(HPMC)-based polymer matrix for enhanced ocular retention. Chitosan and HPMC ratio was optimized and formulation was characterized for various in vitro parameters. The ocular retention was studied on New Zealand rabbits by gamma scintigraphy, which is a very simple and noninvasive technique. For scintigraphy study, the drug timolol maleate was radiolabeled 99… Mehr

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Produktdetails

ISBN: 978-3-8465-8223-7
EAN: 9783846582237
Produktnummer: 37785421
Verlag: LAP Lambert Academic Publishing
Sprache: Englisch
Erscheinungsjahr: 2012
Seitenangabe: 128 S.
Masse: H22.0 cm x B15.0 cm x D0.8 cm 209 g
Abbildungen: Paperback
Gewicht: 209

Über den Autor

Himanshu Gupta had completed his D.Pharm, B.Pharm, M.Pharm, PGDIB, PhD, Post Doc (USA). He is working on ocular drug delivery systems, biomaterials, nuclear medicines and gamma scintigraphic techniques. He published his work in journals of repute and involved with many socities i.e. Organization of Pharmaceutical Unity with BioAllied Sciences etc.