Vandana Singh
DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES
Ionotropic Gelation and Double Desolvation Technique
Buch
Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electr…
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Beschreibung
Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electron microscopy & encapsulation efficiency studies. These studies favorably revealed that the mean particle diameter of optimized formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical morphology. The optimized formulation demonstrated favorable in vitro prolonged release characteristics with zero order, diffusion and erosion mechanisms. Nanoparticles also showed excellent stability. Hence, the designed delivery system can be fine tuned on the depending clinical applications.
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Produktdetails
Weitere Autoren: Chaudhary, Amrendra / Ahmed, Shamim
- ISBN: 978-3-8443-9368-2
- EAN: 9783844393682
- Produktnummer: 37825393
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2011
- Seitenangabe: 92 S.
- Masse: H22.0 cm x B15.0 cm x D0.6 cm 155 g
- Abbildungen: Paperback
- Gewicht: 155
Über den Autor
Vandana Singh,Assistant Professor,chemical Engineering Depart,Mewar University,Chittorgarh,Rajasthan,India.She holds Bachelor of Technology and M.Tech in Chemical Engineering with specialization of Process Modeling and Simulation from A.M.U,Aligarh,U.P.Er.Mahboob Alam,M.Tech (HOD),is a renowned person in field of Process Modeling and simulation
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