Biomarkers in Drug Discovery and Development

Reviews of the first edition:If you are interested in biomarkers, and it is difficult to imagine anyone reading this who wouldn't be, then this book is for you. (ISSX)...Provides a good introduction for those new to the area, and yet it can also serve as a detailed reference manual for those practically involved in biomarker implementation. (ChemMedChem)As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. Continuing the legacy of a well-established pharmaceutical industry reference, the second edition of Biomarkers in Drug Discovery and Development provides perspective, covers recent technological developments, and discusses biomarker characterization and validation.The chapters overview the areas where proper use of biomarkers can substantively impact drug development timelines and costs, enable the selection of better compounds, reduce late stage attrition, and facilitate personalized medicine. Contributing authors from the frontlines of industrial research and development present case studies of biomarkers that have helped and hindered decision making. The new edition updates existing information with developments in genomic sequencing and application of large data sets into pre-clinical and clinical testing; and introduces substantial new materials on data mining, economics, and decision making.With such significant expansion and revision, Biomarkers in Drug Discovery and Development, Second Edition remains a key resource for biotechnology and major pharmaceutical companies, and their efforts to improve and expedite drug development.