A Novel Enantioselective Synthesis of Spiro-Oxindoles
Analogs of Horsifiline and Spirotryprostatin
Spiro-Pyrrolidine-Oxindole is a recurring structural element that has been identified in numerous alkaloids and pharmacologically active compounds. These spiro-fused ring systems embody stereochemical and structural complexities that continue to challenge the synthetic chemist. This book describes a novel enantioselective synthesis of the spiro-pyrrolidine-oxindole ring system in a highly convergent manner.The key steps for the synthesis involve 1,3-dipolar cycloaddition reaction to form the pyrrolidine ring system and radical reaction for the formation of quarternary center. The present synthesis is efficient and would allow pre…
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Produktdetails
Weitere Autoren: Wang, Chih-Hung / Bertucci, Michael
- ISBN: 978-3-8383-5508-5
- EAN: 9783838355085
- Produktnummer: 37836721
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2010
- Seitenangabe: 76 S.
- Masse: H22.0 cm x B15.0 cm x D0.5 cm 131 g
- Abbildungen: Paperback
- Gewicht: 131
Über den Autor
Sesha Sridevi Alluri- A Doctoral student, working with Prof. A. K. Ganguly at stevens Institute of Technology, NJ, USA. She is a co-inventor on two patents and a recipient of several awards and fellowships.
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