1-Amino-2-phenylethane derived sulfonamides
1-Amino-2-phenylethane derived sulfonamides as possible candidates for Alzheimer's Disease
The presented study encompasses the synthesis of a series of sulfonamides derivatives of 1-amino-2-phenylethane in excellent yield by reaction with various aryl sulfonyl chlorides, in the presence of aqueous sodium carbonate solution under dynamic pH control. These projected structures of the synthesized derivatives were characterized by IR, 1H-NMR and EIMS spectral techniques. Moreover, the screening of derivatives against acetyl cholinesterase (AChE), butyryl cholinesterase (BChE) and lipoxygenase (LOX) enzymes rendered these molecules as potent inhibitors of cholinesterase enzymes, relative to Baicalein and Eserine, which were used as refe…
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Produktdetails
Weitere Autoren: Siddiqui, Sabahat Zahra
- ISBN: 978-3-659-60635-9
- EAN: 9783659606359
- Produktnummer: 37430395
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2014
- Seitenangabe: 60 S.
- Masse: H22.0 cm x B15.0 cm x D0.4 cm 107 g
- Abbildungen: Paperback
- Gewicht: 107
Über den Autor
Muhammad Athar Abbasi (Assoc. Prof., GCU, Lahore) is HEC approved supervisor. He is a recipient of Research Productivity Award from 2008-14 from PCST, Pakistan. He has authored 141 research papers.Sabahat Zahra Siddiqui (Lecturer, GCU, Lahore) has authored 40 research publications. She worked as a research scholar at University of Pennsylvania.
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